Hepatitis B surface antigen greater than 250 is commonly found in hepatitis B virus carriers, hepatitis B hepatitis active patients. 1. Hepatitis B virus carriers: Hepatitis B virus carriers generally do not need special treatment, it is recommended to maintain a regular rest in daily life, avoid staying up late, pay attention to quit smoking and drinking, and go to the hospital regularly for the examination of hepatitis B two halves, liver function, and hepatitis B virus DNA, etc., in order to assess whether special treatment is needed. 2. Hepatitis B patients with active hepatitis B: patients with active hepatitis B must be treated with antiviral therapy under the guidance of a doctor, generally using medication, commonly used drugs such as entecavir, lamivudine, etc., but also under the guidance of a doctor to use thiopronin, cotrimoxazole, and other medications to protect the liver treatment. It is recommended to actively communicate with the attending physician to choose the most appropriate treatment plan according to their own situation.