How is idiopathic tremor treated?

  Idiopathic tremor is a relatively common movement disorder. It is characterized by postural tremor and motor tremor 4-12 times per second, involving mainly the arms, but also the head and voice, and rarely the lower extremities. The prevalence of idiopathic tremor is approximately 0.4%-3.9%, with a higher prevalence (4.6%) in people over 65 years of age. Idiopathic tremor is currently considered a benign tremor disorder, but this tremor can lead to embarrassing situations in public speaking, communication, writing, and mannerisms, as well as affect personal life to varying degrees, and can also lead to severe motor dysfunction in severe cases.  The first choice of treatment for idiopathic tremor is medication. The main drugs include propranolol and paracetamol (alias: methotrexate, paroxetine, primidone), which may become less effective as the disease progresses, or may cause some adverse effects with long-term use. Other medications include: convulsants, antipsychotics, antidepressants, and botulinum toxin. Overall, only about 50% of patients experience a reduction in tremor after pharmacological treatment.  Once medication has failed, patients with idiopathic tremor are considered for surgical treatment, which includes stereotactic standard thalamotomy, gamma knife thalamotomy and deep brain stimulation (DBS). The discovery that intraoperative high-frequency stimulation (100 Hz) of the ventral intermediate nucleus of the thalamus (VIM) significantly reduced tremor during thalamotomy in patients with idiopathic tremor by physicians in the 1960s eventually led Benabid and colleagues to apply thalamic DBS to the clinical management of idiopathic tremor.  The DBS system consists of three components: an implanted pulse generator, a lead and an extension cord (which is buried under the skin and not exposed on the body surface). Over the past 20 years, DBS has been effective in the treatment of idiopathic tremor, essentially replacing traditional excisional and destructive procedures, most notably because of its reliable efficacy, high safety profile, and the relative reversibility of adverse effects. Currently, after continuous basic experiments and clinical practice, more and more targets and modulation strategies are used in DBS surgery for idiopathic tremor. This has enabled more patients to benefit.