Children with high fever once every four hours should be treated with antipyretic medication, and the cause of the fever should be identified and treated. For example, acute upper respiratory tract infection caused by bacterial infection requires anti-infective treatment. Fever is a common symptom in pediatrics, for children with fever once every 4 hours, such as temperature over 38.5 ℃, need to use antipyretics (such as ibuprofen or acetaminophen) under the guidance of a physician, and observe the children’s situation, as appropriate, can be repeated at intervals of 4-6 hours to give antipyretics, need to pay attention to poor mental health of the children need to be actively consult the clinic, and can not blindly repeat the use of medication to symptomatic antipyretic treatment. At the same time, the cause of fever should be clearly identified and the treatment is particularly important, such as bacterial infection caused by acute upper respiratory tract infection requires the use of antibacterial drugs such as cefaclor dry suspension anti-infective treatment. For Kawasaki disease, intravenous gammaglobulin and oral aspirin are needed. All of the above drugs should be used under the guidance of a physician, and it is recommended to actively consult a physician to determine the cause of the disease and to have the treatment directed by a specialist.