Metatarsophalangeal joint walking pain does not exclude gout, but shoes that do not fit, interphalangeal neuralgia and tenosynovitis and other factors may also lead to metatarsophalangeal joint walking pain symptoms. 1. Gout: The deposition of uric acid in the joints and surrounding soft tissues can cause gout, mainly manifested as severe joint pain, joint swelling and other symptoms, the pain is generally progressive, most often in the first metatarsophalangeal joints, most of the patients can be relieved within a few days. 2. Ill-fitting shoes: If the shoes worn by the patient are too narrow or too short, the toes are often rubbed by the shoes, which may cause pain in the metatarsophalangeal joints when walking. 3. Interphalangeal neuralgia: Interphalangeal neuralgia can occur in any of the interphalangeal nerves and cause pain in the toe joints, which is aggravated by pressure when walking. 4. Tenosynovitis: Aseptic inflammation of the tendon sheaths due to strain or other factors may also cause pain in the metatarsophalangeal joints when walking. Metatarsophalangeal joint pain may also be caused by other reasons. It is suggested that the patient should go to orthopedics, rheumatology and immunology departments in regular hospitals for further clarification of the specific causes.