Helicobacter pylori-negative, the stomach is still hidden pain, may be related to a variety of irritating factors caused by gastritis, gastric ulcer or duodenal ulcer, functional dyspepsia and so on. Gastric tenderness is not necessarily caused by Helicobacter pylori infection, when the intake of too cold, too hot, hard food or long-term use of aspirin, celecoxib and other drugs, may stimulate the gastric mucosa resulting in inflammatory response, so that the emergence of acute gastritis, chronic gastritis, gastric ulcers, duodenal ulcers, and other diseases, causing gastric tenderness. In addition, when the gastroduodenal dysfunction can cause dyspepsia, can also cause symptoms of gastric occult pain. When the long-term stomach pain, you need to consult a doctor in time, under the guidance of the doctor to clarify the cause of the disease, and active treatment.