Patients with pancreatic cancer usually have elevated levels of tumor markers, usually as a means of evaluating the disease, and aggressive treatment is recommended. Pancreatic cancer is a malignant tumor of the digestive tract with insidious onset, rapid progression, and extremely poor treatment outcome and prognosis. Most patients are diagnosed in the middle or late stage, and may have already developed metastasis. The diagnosis of pancreatic cancer requires a combination of symptoms, serum tumor markers, imaging and pathology, but the definitive diagnosis relies on pathology. Commonly used tumor markers for pancreatic cancer are CA199, CEA, CA50 and so on. However, tumor markers have no absolute relationship with the disease and may be caused by other diseases. The treatment of pancreatic cancer patients mainly includes radical surgical resection, chemotherapy, immunotherapy, targeted therapy, etc. Other treatment options include radiofrequency ablation, cryotherapy, high-energy focused ultrasound, Gamma Knife, radioactive particle implantation and so on. In conclusion, the treatment of pancreatic cancer needs to be judged according to the condition. If pancreatic cancer is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions to avoid delaying the condition.