The treatment of premature ovarian failure at the age of 35 is as follows: 1. Psychological and lifestyle interventions: relieve the patient’s psychological stress, instruct the patient to eat a healthy diet, a high-calcium diet, regular exercise, quit smoking, avoid exposure to reproductive toxic substances, and take appropriate calcium and vitamin D supplements, especially for patients with reduced bone density; 2. Pharmacological treatment: the pathogenesis of premature ovarian failure is not fully The main pharmacological treatment is hormone supplementation, which can not only relieve the symptoms of low estrogen, but also play a primary preventive role against cardiovascular disease and osteoporosis, if there are no contraindications, women with premature ovarian failure should be given hormone supplementation, and patients with secondary amenorrhea need long-term medication, to follow the principles, to seize the moment, in the absence of contraindications, assessment of prudent use. Contraindications, assessment of cautiousness based on the early start of hormone supplementation therapy, followed by grasping the duration, encouraging patients to continue treatment until the average natural age of menopause, which is about 49.5 years for Chinese women, after which the program of postmenopausal hormone supplementation therapy should be referred to and hormone therapy should be continued, grasping the dose, using the standard dose, not emphasizing the small dose and adjusting appropriately according to the needs, all formulated by the physician. Patients with premature ovarian failure should adjust their lifestyle and receive psychotherapy, followed by hormone supplementation therapy with medication follow-up. Once the patient enters the hormone therapy period, follow-up is also important. The patient should have good compliance and should be followed up regularly every year so that the doctor can make a good assessment of the patient in order to carry out hormone therapy in a safe manner, and should also pay attention to the patient’s long-term health and management of complications. Women with premature ovarian failure are prone to osteoporosis, cardiovascular disease, and an increased risk of cognitive dysfunction in later life. Patients must adopt a healthy lifestyle to reduce the adverse effects of risk factors, including weight-bearing exercise, avoiding smoking, and maintaining a normal weight. For patients with genitourinary symptoms such as vaginal dryness and difficulty with intercourse, topical estrogen or vaginal lubricants should be used under medical supervision to improve quality of life.