Tacrolimus is divided into two types: oral and topical. Oral tacrolimus may cause dizziness, headache, nausea, vomiting, generalized fever and many other systemic side effects after ingestion, while individuals may cause erythema, papules, generalized itching, fever and other phenomena. The topical tacrolimus applied to the skin surface may cause local skin irritation, redness, burning, itching, and in individuals, vesicles and oozing. Therefore, once the drug Tacrolimus is used on the human body, stop using the drug as soon as side effects occur and replace it with other alternative drugs for the treatment of the disease.