Hepatitis B Penta 1245 positive is generally an intermediate transitional state after hepatitis B infection. Hepatitis B penta 1245 positive, refers to hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B e antibody, hepatitis B core antibody positive, indicating that the patient is a hepatitis B carrier, currently already belongs to the infection of hepatitis B virus transition state. At this time, it is necessary to supplement the examination of liver function, liver ultrasound, etc. If the liver function is normal, it means that it is a healthy carrier often does not need to take any treatment. However, if the liver function test is abnormal and the transaminase and bilirubin are elevated, it means that the viral load in the body is relatively high, and antiviral treatment is often needed. It is recommended to cooperate with the doctor to take liver function tests in a timely manner, so as to clarify the diagnosis and then target treatment or therapy.