Lip blistering and itching discomfort is usually caused by allergic labiitis, chronic labiitis or herpes simplex, the treatment is mainly drug therapy, as follows. 1. Metaphylactic lipitis: give antihistamines, such as loratadine, chlorpheniramine, in addition to intravenous injection of 10% calcium gluconate plus vitamin C can reduce exudation, reduce inflammation. 2. Chronic lipitis: antibiotic ointment or hormone ointment can be used, such as gentamycin ophthalmic ointment, tretinoin cream, etc., or local injection of tretinoin liquid, prednisolone suspension can help promote healing. 3. Herpes simplex: apply 3% acyclovir ointment, 1% penciclovir cream or phthalbutamide cream. All of the above medications should be used under the guidance of a doctor. It is recommended to visit a hospital in time to receive professional treatment.