The conversion of major triple-positive to minor triple-positive refers to the conversion of a person infected with the hepatitis B virus from E antigen-positive to E antibody-positive. There are two cases: the first one, the body’s immune system activates and clears the virus spontaneously, turning from major triplet to minor triplet; the second one, patients with major triplet can weaken the hepatitis B virus replication by taking hepatitis B antiviral drugs, and then turn from major triplet to minor triplet. Major triple-positive refers to 1, 3 and 5 positivity in the five items of hepatitis B, while minor triple-positive refers to 1, 4 and 5 positivity in the five items of hepatitis B. Generally, patients with major triple-positive disease are more likely to have positive hepatitis B virus DNA and normal or abnormal liver function, while patients with minor triple-positive disease need antiviral treatment when their liver function is abnormal. The hepatitis B virus is relatively inactive and less contagious in patients with minor triplets, but even in minor triplets, some patients are accompanied by positive hepatitis B DNA. Overall, the change from major to minor hepatitis B is a change for the better.