The lack of effect of taking Nephrolithone Granules is related to the specific condition and not taking it for enough time. Nephrolithone Granules is composed of Qiancheng, Wangbuliuhang (fried), Polygonum aviculare, Yanhuisuo (vinegared), Jienneijin (scalded), Salviae Miltiorrhizae, Mucuna pruriens, Qu Mai, Cow’s Knee, and Hai Jin Sha. Nephrolithone Granules has the effects of removing stones, dissolving stones, activating blood circulation to relieve pain (relieving pain by removing blood stasis), clearing heat and inducing dampness (removing heat and dampness from the body). The adverse reactions and contraindications of Nephrolithone Granules are not clear. If the stones are larger or more numerous, it may be difficult to expel them by taking Nephrolithone Granules, and prompt medical attention is needed, and ultrasonic lithotripsy and other methods can be used to help expel the stones. Nephrolithone granules can not be taken once or twice to see the effect, it is recommended that under the guidance of the doctor to adhere to take. Kidney stone through the taking of professional Chinese medicine doctor’s guidance and help, to avoid the wrong medication aggravate the symptoms.