Although an occasional sleep apnea can cause some transient changes in the body, but will not cause much harm to human health, however, this kind of apnea occurs repeatedly for a long time, night after night, year after year, its harm is not to be taken lightly. 1, cardiovascular system: (1) hypertension: 40% to 60% of patients with obstructive sleep apnea syndrome have a history of hypertension, unlike other hypertensive patients, their blood pressure is mostly highest in the morning, early morning headache, dizziness is obvious, the effect of simple drug treatment is poor. After effective treatment of apnea, hypertension often decreases, and in some cases, it can even drop to the normal range. (2) Pulmonary hypertension, pulmonary heart disease, right heart failure: 10% to 20% of patients with sleep apnea syndrome will develop arterial hypertension, the prevalence of pulmonary hypertension in patients with moderate and severe sleep apnea syndrome can reach 55%, in combination with lung disorders (such as chronic bronchitis, emphysema), sleep apnea is more likely to lead to increased pulmonary artery pressure, increasing the workload of the right ventricle and right atrium The main manifestations of pulmonary heart disease and right heart failure are leg swelling and shortness of breath. In China, the most common cause of right heart failure is chronic bronchitis and emphysema, but we found that obese patients without a history of pulmonary disease can also develop clinical manifestations of right heart insufficiency after years of sleep apnea. (3) Altered left heart function: Echocardiography and autopsy revealed that the long-term occurrence of sleep apnea can increase the weight of the left heart, thicken the ventricular wall, and reduce the amount of blood ejected from the heart per beat, and these pathological changes subsequently improve after the application of positive airway pressure ventilation therapy to improve sleep apnea. (4) Ischemic heart disease: Ischemic heart disease mainly includes angina pectoris and myocardial infarction, and hypoxia is an important cause of angina pectoris. Studies have shown that sleep apnea is one of the risk factors for ischemic heart disease. Dynamic electrocardiogram examination reveals that the occurrence of ST-segment drop during sleep in patients with sleep apnea syndrome is very frequent, suggesting cardiac ischemia and hypoxia. Especially in patients with pre-existing heart disease, factors such as hypoxia caused by apnea, autonomic dysfunction and combined hypertension can accelerate the development of atherosclerosis and induce angina pectoris or even myocardial infarction. (5) arrhythmia: sleep apnea syndrome patients sleep with alternating fast and slow heart rate, heart rate fluctuations, mostly sinus tachycardia, but also short bursts of atrial or ventricular tachycardia, slow heart conduction block, cardiac arrest, almost half of the sleep apnea syndrome patients will have a variety of arrhythmias, some even fatal. Monotherapy of sleep apnea can often achieve good results. However, it is easy to be misdiagnosed as heart disease and mistreated. 2, the nervous system: (1) cerebrovascular disease: we know that cerebrovascular accidents, commonly known as strokes, occur at night, and overnight, the patient will have a distorted mouth and eyes and paralyzed limbs. Studies have found that snoring and apnea during sleep can increase the morbidity and mortality of cerebrovascular disease. more than 53% of male cerebrovascular patients have a history of long-term habitual snoring, and 35% of patients with cerebrovascular accidents occurring during sleep are closely related to snoring and apnea. More and more evidence shows that snoring and apnea is an independent risk factor for cerebrovascular disease and has a very important role in the occurrence and aggravation of cerebrovascular accidents. (2) Excessive drowsiness: frequent awakenings caused by sleep apnea can seriously disrupt the patient’s sleep, the deep sleep period is reduced or even disappears, and the patient is in a state of chronic sleep deprivation. The severity of daytime sleepiness is closely related to the severity of sleep apnea syndrome. Daytime sleepiness and drowsiness can seriously affect work, study and life, especially for drivers and patients engaged in high-altitude work, with a high accident rate, which can endanger their own lives and the lives of others. (3) mental and psychological hazards: mental retardation, personality and behavioral abnormalities, and sleep apnea syndrome has a clear relationship; sleep apnea syndrome patients and family members, interpersonal relationships between colleagues are often less harmonious; depression and other mental illnesses can also be seen in patients with sleep apnea syndrome; some studies also found that sleep apnea and the occurrence of Alzheimer’s disease also have a certain relationship. (4) Endocrine metabolic system: hypersexuality or impotence is more common in men with sleep apnea syndrome. Statistics show that 44% of 50 cases of sleep apnea syndrome patients have different degrees of sexual dysfunction. Recent studies also show that endocrine metabolic dysfunction caused by sleep apnea can aggravate obesity. (5) Blood system: many patients with sleep apnea syndrome have more red blood cells in the blood, hemoglobin is greater than 160 grams per liter, exceeding the normal range, and blood viscosity increases, which is due to long-term apnea caused by hypoxia, and the compensatory proliferation of red blood cells in the blood in order to carry more oxygen, and changes in the content of other endocrine elements in the body caused by increased urination resulting in blood concentration and other factors It is also an important factor that causes the increase of red blood cells in the blood. (6) Renal function: Patients with sleep apnea syndrome have increased urine output at night during sleep, up to three times or more, and some patients have increased protein content in urine. Mortality from many diseases is increased at night, especially some sudden deaths of unknown cause, i.e. sudden death, which often occur at night. Doctors often attribute this to cardiac arrest, but the cause of cardiac arrest is unknown in many patients. Sleep apnea syndrome is one of the culprits causing sudden death at night. 460 cases of sudden death occurred after autopsy, apnea is one of the risk factors for death at night in patients with cardiovascular disease, and habitual snorers have increased mortality at night. Recent studies also show that the 5-year mortality rate of patients with untreated sleep apnea syndrome is 11% to 13%; patients with more than 20 apnea per hour have an 8-year mortality rate of 37%; patients with less than 20 apnea per hour have a mortality rate of only 4%; after effective treatment with tracheotomy or positive pressure ventilation, the mortality rate also decreases significantly; while simple ENT surgery Excision of the soft tissues of the oropharynx, treatment often fails and does not improve the survival rate of patients. We have summarized 70 cases of sleep apnea syndrome patients with different severity of the disease and found that the average age of the severely ill patients with sleep breathing disorder more than 40 times per hour was only about 45 years old, which was significantly lower than the average age of the patients in the less severe group; it was also found clinically that there were few severely ill patients over 65 years old, suggesting that the life expectancy of patients with severe sleep apnea syndrome was shortened.