Botox just sounds like a scary name. And it is true, botulinum toxin is a highly toxic agent, a very small dose can cause death, so why can we apply it safely? Why is its application in cosmetic surgery in full swing and popular all over the world? This is because the concentration and dosage of our application is far below its safety limit, so it is very safe. So what is the principle of Botox for wrinkle reduction? The reason why botulinum toxin has the effect of removing wrinkles is because it can inhibit the release of acetylcholine from the presynaptic membrane of the peripheral motor nerve endings, blocking the transmission of information between the nerve and the muscle, thus causing flaccid paralysis of the muscle. Our human wrinkles are mostly the result of facial expression muscles, and Botox paralyzes the muscles so that the muscles do not have the ability to pull and stretch or eliminate the wrinkles. Botulinum toxin injection has the characteristics of small trauma, quick effect, convenient operation, inexpensive, and does not affect the work and so on. Compared with traditional chemical peeling, facelift, collagen injection, fat charging or small incision wrinkle removal, it only requires a certain dose of botulinum toxin to be injected into the surgical area, and the whole process only takes a few minutes and is almost painless. Botox for wrinkles is time-sensitive. After injecting Botox into the wrinkles, the wrinkles will gradually flatten out after 1 to 7 days. And the maintenance of wrinkle reduction effect is usually 3 months to 6 months. To maintain long-term cosmetic effects, injections are required 2 to 3 times per year. It is understood that using Botox to remove wrinkles, general crow’s feet, forehead lines, frown lines, back of the nose and neck wrinkles can be removed. However, it is best suited for early, less visible wrinkles. If the patient’s wrinkles are deep, it can be combined with tissue fillers (e.g. hyaluronic acid, etc.); if the skin is very loose, traditional skin lifting surgery can be considered. So, Botox wrinkle removal is not a panacea, but its definitive results and minimal complications make its application the number one cosmetic surgery procedure. It is worth noting that Botox for wrinkles should not be used on pregnant women, lactating women, patients with myasthenia gravis, allergy sufferers, ptosis sufferers and patients with internal diseases such as heart, liver, lungs and kidneys.