There is currently no clinical regimen in which glucagon can be used as a complete replacement for insulin. Glucagon is a long-acting insulin analog that can be used to treat adults with type 1 and type 2 diabetes mellitus, and there is currently no clinical alternative to glucagon as a complete replacement for oral hypoglycemic agents. Common adverse effects of glucagon include hypoglycemia, local allergy such as redness, swelling and itching at the injection site, and possible lipodystrophy at the injection site. It is contraindicated for those who are allergic to insulin glargine and during hypoglycemic episodes. Patients with hepatic and renal insufficiency are more prone to hypoglycemia, and blood glucose should be monitored frequently during use. Patients who need to change their insulin with Glycine Insulin are recommended to go to the hospital, consult a professional doctor and adjust under the doctor’s guidance.