Chest tightness and breathlessness at night with pressure sensation in the chest may be caused by emotional fluctuations, heart valve disease, coronary heart disease, lung tumor and other reasons. 1. Emotional fluctuations: patients in violent emotional fluctuations, generally lead to hypoxia, sympathetic nerve excitation and other conditions, then there may be chest tightness and shortness of breath, chest pressure symptoms. It is generally recommended that patients calm their emotions to relieve the symptoms. 2. Heart valve disease: due to organic or functional lesions of the heart valves, affecting the normal ejection function of the heart, unable to achieve normal blood circulation requirements, ventricular and atrial compensatory enlargement, which causes chest tightness at night, breathlessness, chest pressure and other symptoms, and in severe cases, heart failure. 3. Coronary heart disease: patients with angina pectoris caused by coronary artery stenosis, occlusion, insufficient blood supply to the myocardium will also be accompanied by chest tightness and breathlessness, chest pressure. It usually appears for several minutes and will be significantly relieved after resting. 4. Lung tumors: lung tumors invade normal lung tissues and affect the respiratory function, or lung tumors with large size produce compression symptoms, or malignant lung cancer produces cancerous hydrothorax, which will lead to chest tightness at night and oppression in chest. Chest tightness and breathlessness at night with pressure in chest may be caused by many reasons, patients should go to the hospital in time for consultation and standardized treatment to clarify the cause of the disease.