Tumor biotherapy is a new therapy that applies modern biotechnology and its products for tumor prevention and treatment. Tumor biotherapy achieves anti-tumor effects by mobilizing the host’s natural defense mechanism or by giving naturally (or genetically engineered) produced substances with strong targeting properties. Tumor biotherapy includes somatic cell therapy and cytokine therapy, tumor vaccine and dendritic cell therapy, tumor molecular targeting therapies, anti-EGFR human/mouse chimeric monoclonal antibody therapies, and novel humanized monoclonal antibody therapies against vascular endothelial growth factor receptor, etc. With the advancement of science and technology, more and more therapies for treating tumors will be available. Tumor patients are advised to go to the hospital in time and take active treatment so as not to delay their condition.