The management of two-hour postprandial blood glucose 4.0 mmol/L on glimepiride includes taking sugary foods by mouth and adjusting the dose of the medication. The normal two-hour postprandial blood glucose range is 4.4 to 7.8 mmol/L. When the patient’s two-hour postprandial blood glucose 4.0 mmol/L is low after taking glimepiride treatment, he or she may experience hunger, palpitations, cold sweat, etc. At this time, it is necessary to consider hypoglycemic episodes, and sugar-containing foods should be supplemented, such as candies, cookies, chocolates and so on. In addition, the occurrence of low blood glucose two hours after meals also needs to be considered to be caused by too large a dose of medication, you need to adjust the dose of medication under the guidance of the doctor. Glimepiride is a drug for the treatment of diabetes, and the possible adverse reactions are hypoglycemia, nausea, vomiting, hair loss and so on. Glimepiride is contraindicated in allergy, pregnancy, breastfeeding, and type 1 diabetes. The application of Glimepiride needs to be carried out under the supervision of a doctor. In case of abnormal blood glucose values it is recommended to visit the hospital and ask the doctor to make a judgment and give a plan of treatment.