Low cortisol and hypothyroidism first treatment of low cortisol is mainly to avoid the emergence of adrenal crisis, to avoid aggravation of the disease. Low cortisol can be seen in hypoadrenocorticism, when there is hypothyroidism with hypoadrenocorticism, you need to treat the hypoadrenocorticism first, usually using glucocorticoid therapy, such as hydrocortisone, and then use levothyroxine sodium tablets for replacement therapy. If the treatment of hypothyroidism first will increase the burden on the adrenal cortex, it may further aggravate the hypoadrenocorticism or even cause adrenal crisis, which may endanger the patient’s life. Therefore, patients with low cortisol and hypothyroidism should be treated first for low cortisol and supplemented with glucocorticoids before treating hypothyroidism. In this case, it is recommended to go to the hospital, consult with a professional doctor and cooperate with the doctor for active treatment.