Ozone therapy for the knee is usually done 3 to 5 times, possibly more if the patient has more severe pain. Knee ozone therapy focuses on ozone being injected into the lesion through specialized instruments to remove bacteria and repair damaged tissue. The oxidizing effect of ozone causes the inflammation to subside, thus achieving pain relief. The number of sessions of ozone therapy for knee joints is determined by the specific degree of the patient’s condition. If the condition is mild, 3 to 5 sessions of ozone therapy are usually enough to relieve the symptoms. However, if the condition is more severe and recurrent, the number of ozone treatments will increase.