Elderly patients with combined hypertension often exhibit a significant increase in blood pressure at night, which is a non-arrythmic manifestation. The best treatment for nocturnal hypertension is to use long-acting antihypertensive drugs, i.e., the duration of action is maintained for 24 hours to ensure the nighttime effect. This part of the patient can also change the time to take the medication, such as once a day to take the medication in the afternoon or before bedtime, to be able to control the morning peak blood pressure in the morning, which is the high incidence of cardiovascular and cerebrovascular events. Patients must pay attention to nocturnal hypertension, adjust the time of taking medication, and try to use long-acting antihypertensive drugs to maintain smooth pressure reduction for 24 hours. Clinically used long-acting antihypertensive drugs, the elderly are suitable for taking CCB class, dihydropyridine class antihypertensive drugs, common drugs are amlodipine or levamlodipine, benidipine, cilnidipine, lacidipine, and ACEI, ARB class antihypertensive drugs, the vast majority of them are long-acting antihypertensive drugs. Other drugs include epril, ramipril, lenopril, and perindopril, as well as sartans, such as olmesartan, temisartan, or colesartan, valsartan, and other drugs. There is also a large class of diuretics, because the blood pressure of the elderly is more stubborn, the addition of diuretics, its antihypertensive strength is also very good for patients with stubborn hypertension.