The method of plasma replacement includes: 1. Separate the patient’s plasma through a plasma separator, and the remaining whole blood components are mixed with normal plasma and imported into the patient, with a plasma consumption of about 2000-3000 ml each time; 2. Separate the patient’s plasma through a plasma separator, and the separated plasma passes through an immunosorbent column to adsorb antibodies harmful to the body, and the remaining plasma is transfused back into the patient, with supplemental albumin or surrogate The remaining plasma is returned to the patient and supplemented with albumin or plasma substitute. This method has less plasma loss and relatively less impact on the patient.