Taking antihypertensive drugs or high blood pressure may be caused by irrational drug dosage, irrational drug category, secondary hypertension and other reasons. 1. Unreasonable drug dosage: When taking anti-hypertensive drugs, if hypertensive patients do not strictly follow the doctor’s advice, blindly increase or decrease the drug dosage, take the drug irregularly or stop taking the drug, it may lead to high blood pressure not coming down. 2. Unreasonable drug category: If the blood pressure of hypertensive patients does not come down after taking medicines, it may be caused by irrational choice of medicines or taking other medicines by mistake, especially taking short-acting antihypertensive medicines is more prone to the situation that the blood pressure does not come down or is not well controlled with big fluctuation. 3. Secondary hypertension: patients with secondary hypertension may not see their blood pressure drop after taking anti-hypertensive drugs, which is caused by the lack of targeted treatment for the primary disease. For example, hypertension caused by renal artery stenosis or chronic kidney disease, at this time, in addition to taking antihypertensive drugs, but also on the primary disease treatment and treatment. Hypertensive patients should avoid drinking alcohol and pay attention to daily living habits during the medication period. The medication should be taken in accordance with the doctor’s instructions, and pay attention to monitoring the blood pressure situation, please consult a doctor in time when discomfort occurs.