Treatment of Legionella pneumonia is preferred to antibiotics because Legionella is a bacillus for which antibiotic treatment is effective, and erythromycin is generally preferred for treatment. Legionella is also called Legionella pneumophila and is primarily an intracellular parasite in nature. Therefore, when Legionella pneumophila infection occurs, it is necessary to use drugs that can penetrate into the cells for antibacterial treatment, and in addition to entering the cells, it is also necessary to maintain the level of drugs in the cells, so the choice of drugs is relatively strict. Erythromycin is generally preferred for the treatment of Legionella pneumonitis, mainly because it can effectively kill bacteria and has the most successful experience in clinical application. However, when the patient’s immunity is low, the use of immunosuppressants and the condition is more serious, generally preferred fluoroquinolones for treatment (such as common oxfloxacin, levofloxacin, etc.), this kind of bactericides bactericidal effect is stronger than erythromycin, but there are certain adverse reactions. Because of the rapid progress of Legionella pneumonitis, the lethality of not doing treatment is high. Therefore, once diagnosed, it is necessary to be hospitalized in a timely manner, and at the same time, good personal protection to avoid entering crowded places, which increases the risk of infecting others.