The increasing number of diabetic patients has led to an increase in social burden and psychosomatic diseases. Especially for elderly patients, maintaining a good attitude and the right attitude towards the disease is crucial to the control of blood sugar and the improvement of quality of life. In the outpatient clinic, we often encounter some diabetic patients with the same onset time and condition, but due to different attitudes and methods of treating the disease, the results can be very different, some patients can treat the disease correctly, both to come, then rest. They actively cooperate with doctors, master the necessary scientific knowledge, feel comfortable, their blood sugar is well controlled, their work life is not affected at all, many complications are also rejected, and they have developed good eating and living habits, and they often show up and make contributions to society and the public. Some patients, on the other hand, complain about the sky, sigh all day long, can’t eat, can’t sleep, take medication on time, seek prescriptions in the east, seek secret recipes in the west, the result is more and more disease, really become a medicine jar, sick child, not only chronic diseases, and due to the decline in resistance, immunity, summer wind, winter colds, early away from normal life and healthy interactions, depression will come unexpectedly. In layman’s terms, depression is an abnormal and unhealthy state of mind and emotional performance, mainly manifested as no desire, no demand, no hope, lack of interest in anything, thinking badly about everything, and eventually will lose the courage to live and go to despair. The occurrence of diabetic depression is the result of a combination of endogenous and exogenous factors. The gender, age and family history of diabetic patients are related to the occurrence of depression, while the degree, duration and severity of complications of diabetes are also independent risk factors for depression. The treatment of diabetic depression includes psychotherapy and medication, psychotherapy includes the understanding of diabetes and self-monitoring, first of all, we should have a correct understanding and scientific attitude towards diabetes, although it is a chronic disease that accompanies people throughout their life, but as long as we treat it seriously, it is completely possible to live with human beings in peace. Secondly, good mood can mobilize the body’s immune and endocrine system in a good balance to keep the blood sugar stable, while bad mood and emotional instability make the body constantly in a state of stress, leading to the rise of glucagon, not only to increase blood sugar, but also can cause blood pressure, neurological disorders and lipid metabolism disorders. Therefore, the most basic treatment for diabetic patients is to develop good eating habits and lifestyle, such as the control of the amount of diet and a reasonable mix of dietary ingredients, appropriate exercise can also make people feel better and sleep better, which is conducive to the control of blood sugar and enter a virtuous cycle. In addition, the occurrence of depression will also increase in diabetes itself due to changes in certain neuropeptides and damage to the nervous system from hyperglycemia and glucose metabolites. Therefore, diabetic patients should not develop an inferiority complex and go to consciously close themselves, but should integrate more into normal life and communicate more with people, and in depressed patients whose lives are seriously affected, they should be treated with medication if necessary. The current antidepressants are the following three: monoamine oxidase inhibitors, tricyclic antidepressants and selective serotonin reuptake inhibitors. Monoamine oxidase inhibitors were the first antidepressants discovered, and have been largely replaced by tricyclic antidepressants due to serious toxic side effects. Tricyclic antidepressants are currently the most widely used antidepressants, represented by promethazine, other more commonly used are chlorpromazine, amitriptyline, doxorubicin, etc.. Such drugs can not only improve mood, but also have a sedative effect, and have a better therapeutic effect on insomnia symptoms. In recent years, the introduction of heterocyclic antidepressants, so that depressed patients have more options, including: 1, tetracyclic antidepressants: Maputilin (Maputilin, Lutimex) as the representative, not only has an antidepressant effect, sedative effect is also strong, the efficacy is similar to tricyclic antidepressants, with light side effects. 2, not to inhibit the uptake of amine drugs: Mianserin as the representative. This drug has sedative, anxiolytic and antidepressant effects, effective for depression, anxiety, suicidal ideation, somatization symptoms and insomnia. It has mild side effects and a high safety profile and is suitable for older patients. Selective serotonin reuptake inhibitors are a new type of antidepressant drugs, mainly five kinds of fluoxetine (fluoxyprofen, Prozac), paroxetine, fluoxetine, sertraline and aminoglutethimide. They are highly targeted and have few side effects, and have been widely used in clinical practice. In addition, the presence of a mood disorder has an extremely detrimental effect on the treatment of diabetes because depression may induce or promote somatic diseases, aggravate the pain of somatic diseases, and cause aggravation of the primary disease. If a depressive disorder is diagnosed, antidepressant treatment should be given regardless of whether it is primary or secondary. Therefore, diabetic patients should pay attention to their mood changes, treat depression in a timely manner, and carry out reasonable psychological guidance and medication, which can not only improve their mood, but also accelerate the recovery of diabetes and improve their quality of life. To sum up, diabetes with depression can be completely controlled through the joint efforts of patients and doctors, and it is important to build up confidence and stay away from depression.