Colchicine can inhibit the chemotaxis of leukocytes, thus reducing the inflammatory response and relieving pain, but the therapeutic dose of colchicine is very close to the toxic dose, and some patients cannot tolerate it after taking it, and will have diarrhea and other gastrointestinal reactions, so you can take oral diclofenac sodium, a non-steroidal analgesic drug, for anti-inflammatory Pain relief. When the patient’s pain is controlled, in order to avoid another attack of big toe gout, continuous uric acid-lowering medication is needed during the interval when the joint is not painful.