In recent years, the number of patients with craniosynostosis has gradually increased, and there are many causes of craniosynostosis, which seriously affect the health of patients after craniosynostosis. What are the specific causes of skull defects? Craniosynostosis is an interruption of the anatomy of the skull, which is incomplete. There are several reasons for cranial defects: the first is the cranial defect left after open skull fracture or firearm penetration injury; the second is the cranial defect left after hematoma removal and decompression; the third is the cranial defect left after removing the diseased cranial bone. If the extent of the defect is relatively small, there can be no clinical symptoms; if the extent of the defect is relatively large, cranial defect syndrome can appear, mainly manifested as headache, dizziness, nausea, vomiting, memory loss, hand tremor, etc.; there are also some patients, if the cranial defect is very serious, forming a very serious compression of brain tissue, epilepsy will appear. If epilepsy occurs, some treatment is needed. The diagnosis of cranial defects can be made by physical examination, plain film and CT head examination, which can reveal the destruction of the integrity of the skull. If the skull defect is large, generally in medical terms, skull defects >3 cm or larger require surgery. We carry out new polyether ether ketone peek material as skull repair, peek material can accurately replicate the human skull defect part, based on CT data through advanced 3D printing technology to reconstruct the design, and the defect area to precisely match, to meet the high requirements of patients for the recovery of the wound at the perfect. peek is a good material for patients quality choice.