It is not recommended to apply pimecrolimus three or four times a day. Typically, this medication is used twice daily. Pimecrolimus Cream is primarily used to treat patients 2 years of age and older with mild to moderate atopic dermatitis who are not immunocompromised. Short-term treatment of signs and symptoms of the disease and long-term intermittent treatment to prevent exacerbations. This medication is administered by applying a thin topical layer of pimecrolimus cream to the affected skin twice daily. Adverse reactions such as burning sensation, itching, and folliculitis may occur with the use of this medication, usually mild or moderate, and prompt discontinuation of the medication and medical attention is recommended. Patients with known hypersensitivity to pimecrolimus or any other excipient in this medication need to be disabled. Patients are also advised to use Pimecrolimus Cream under the supervision of a doctor and not to use it privately.