All three belong to the proton pump inhibitor, omeprazole side effects are relatively more, rabeprazole faster effect, pantoprazole stronger, should choose the right drug for the condition, there is no so-called which is better. Omeprazole, rabeprazole, pantoprazole belong to the proton pump inhibitors, all can inhibit the secretion of gastric acid, suitable for gastric ulcer, gastroesophageal reflux and other diseases. Omeprazole is a first-generation proton pump inhibitor, suitable for the treatment of duodenal ulcer, etc. However, the drug is poorly stabilized and needs to be stored at low temperature and protected from light. Side effects are relatively large, and adverse reactions such as headache and nausea may occur. There is no data on the use in pregnant and lactating women. Rabeprazole has a fast onset of action after taking it, and it is more effective in treating Helicobacter pylori infection, which is more suitable for gastroesophageal reflux, gastric ulcer, etc. Pregnant women can use it only if the beneficial effects outweigh the dangers. Pantoprazole is stable, strong inhibition of gastric acid, long duration of action, the use of data for pregnant women is not clear, severe hepatic impairment should be adjusted under the guidance of a doctor’s dose. Rabeprazole, pantoprazole side effects are relatively small, relatively high safety, occasionally seen vomiting, nausea and other adverse reactions. Allergic to these three drugs are prohibited. Omeprazole, Rabeprazole, Pantoprazole have oral enteric-coated tablets, capsules, injections and other dosage forms, and there are differences in onset of action time, strength of efficacy, applicability, therapeutic advantages, etc. If you need to take these drugs, you should use them reasonably under the guidance of a doctor, do not use them for a long time, so as not to avoid adverse reactions.