Oxyfloxacin should not be used after its expiration date. Oxyfloxacin or any kind of medicine can not continue to take after the expiration date, because the drug has a shelf life, within the shelf life can determine the efficacy of the drug. If the drug expired, may not be able to see obvious changes in the appearance, but can not guarantee the quality and efficacy of the drug, which leads to a reduction in efficacy, in the treatment of disease, can not play a significant role, and even the stability of the deterioration, resulting in a number of other situations, such as toxicity, adverse reactions to increase. After the expiration date of Ofloxacin, you must throw away the drug and replace it with a drug within the expiration date, and the drug should be taken under the guidance of a doctor, not to take it on your own.