Severe insomnia on duloxetine may be caused by adverse drug reactions, incorrect medication, or low dosage of medication, etc. Patients can take appropriate medication for the cause of the illness under the guidance of a professional doctor. 1. Adverse drug reactions: Duloxetine can be used to treat depression and anxiety disorders. When patients take this drug for a long time, it may cause insomnia, headache and other adverse reactions to the body. Patients should pay attention to timely consultation with the doctor, follow the doctor’s instructions to adjust the dosage, can reduce the adverse reactions to the body’s stimulation. 2. medication is not appropriate: taking duloxetine severe insomnia, may also be caused by the medication is not appropriate treatment, the patient should stop taking duloxetine in time, and under the guidance of the doctor to choose the appropriate drug for treatment. 3. less dosage: when patients change the dosage by themselves, it may lead to less dosage, which is not conducive to the proper therapeutic effect of the drug, and this can also cause severe insomnia. Patients should consult their doctor in time and resume the normal dosage of the drug, which will help to exert the effect of the drug to alleviate the above symptoms. It is recommended to choose the appropriate medication for treatment according to the condition, under the guidance of a professional doctor, and follow the doctor’s instructions for the correct use of medication.