Posterior tooth pain with half of the face is a relatively common clinical condition, and the more common diseases that cause this condition are acute pulpitis and pericoronitis. Acute pulpitis of the posterior teeth is typically characterized by radiating pain, which often radiates to the auriculotemporal region, causing pain on half of the face. Pericoronitis of the wisdom tooth also causes radiating pain, causing pain in the corresponding half of the face. Both of these diseases can be said to be caused by bacterial infections. Therefore, for this pain, some anti-inflammatory and pain-relieving medications can be considered. Commonly used painkillers we generally recommend the application of pain first-order antipyretics and analgesics, commonly aspirin, ibuprofen, etc. The application of anti-inflammatory drugs we generally recommend for the oral cavity can be considered to apply cephalosporins and nitroimidazoles, through these two antibiotics can better inhibit the growth of pathogenic bacteria in the oral cavity. But for these pain 1 must explain that the method of taking medicine is to treat the symptoms but not the root cause. The best way is to go to a professional dentistry department to treat the tooth, for acute pulpitis, should be open pulp drainage treatment, the pain will be immediately relieved. For wisdom tooth pericoronitis, local treatment combined with systemic medication should be used to control the pain and then extract the tooth to cure the disease.