Intermediate and advanced pancreatic cancer is one of the malignant tumors with poor prognosis. Since most patients have lost the chance of surgical treatment at the time of diagnosis, it is often difficult to obtain satisfactory and satisfactory results even with the implementation of conservative medical treatment. In recent years, with the continuous progress and development of clinical medicine and material science, non-surgical treatment methods for inoperable intermediate and advanced pancreatic cancer have emerged, such as freezing, radiofrequency, microwave ablation, HEFA knife, particle placement and other techniques. However, the latest research shows that among many non-surgical treatment methods, argon helium cryoablation is the best. This method is not only less invasive and has fewer side effects, but also can rapidly reduce the tumor load, and the long-term survival benefit is significantly better than other treatment techniques, which plays a very important role in improving the overall prognosis of pancreatic cancer patients. Indications for argon helium cryotherapy: (1) Patients with intermediate to advanced pancreatic cancer who cannot undergo conventional surgical resection. (2) Patients with intermediate to advanced pancreatic cancer who cannot tolerate surgical resection, but have limited lesions and no distant metastases. (3) Patients with painful symptoms that seriously affect their quality of life. (4) Combined with radiotherapy to improve the therapeutic effect.