After ruling out the corresponding drug contraindications of Liuzasulfapyridine and Tretinoin, patients whose condition requires it can take Liuzasulfapyridine and Tretinoin at the same time. Sulfasalazine is a kind of drug with immunomodulatory effect, which is mainly used for the treatment of Crohn’s disease, ulcerative colitis and rheumatoid arthritis, etc. The main ingredient of tretinoin tablets is tretinoin polypeptide, which has the efficacy of removing dampness and swelling, relaxing meridians and activating collaterals, and it can be used for the treatment of rheumatoid arthritis, leukoencephalopathy, nephrotic syndrome and autoimmune hepatitis and other diseases. At present, no drug interaction has been found between Liuzasulfapyridine and Radix Rehmanniae, patients whose condition requires it can take these two drugs at the same time, but should exclude the contraindications of the corresponding drugs, the contraindications of Liuzasulfapyridine are intestinal obstruction, urinary tract obstruction, porphyria, and allergy to sulfonamides and salicylates. Cardiac, renal and hepatic insufficiency, children, patients with severe anemia, patients with decreased white blood cells and platelets, patients with gastric and duodenal ulcers, patients with severe cardiac arrhythmia, pregnant and lactating women and other patients with contraindications to the use of tretinoin therapy is not allowed. Sulfasalazine and tretinoin should be used under the guidance of a physician, and patients are advised to go to the relevant departments of regular hospitals for detailed consultation.