Progesterone affects fibroids and can encourage their growth and development, as well as further growth. Therefore, it is important to tell your doctor that you have fibroids at the time of your visit. Treatment is also done with antagonists of progesterone with progesterone receptor antagonists to treat fibroids. After using progesterone, fibroids will grow, but not all of them will grow with progesterone, because some fibroids are progesterone-dependent, so progesterone will promote the growth of fibroids in these patients, while estrogen will not have any effect. It is also important to distinguish between estrogen-dependent, progesterone-dependent, or high estrogen receptors and high progesterone receptors in the expression of leiomyosarcoma, so the appropriate treatment and medication should be targeted.