The main mechanism of oral ulcers caused by taking Anrotinib is drug-induced epidermal damage and activation of inflammatory factors, and the clinical treatment is based on symptomatic treatments such as promoting healing and anti-inflammation, as follows. 1. Promote healing: recombinant human epidermal growth factor gel or topical solution, recombinant bovine basic fibroblast growth factor gel or topical solution. 2. Anti-inflammatory: commonly used drugs include 0.1% tretinoin ointment, 3% compound borax solution, chlorhexidine solution, povidone-iodine solution and so on. All of the above drugs need to be used under the guidance of a doctor. If the symptoms of mouth ulcers are serious, or continue to be unimproved, it is recommended to go to the hospital in a timely manner, for formal targeted treatment.