Both azelaic acid gel and clindamycin gel are medications for acne. There is no such thing as which one is better, as long as the right one is the best. 1. azelaic acid gel: is a dermatology topical drug and local treatment drugs, clinically mainly used for the treatment of mild and moderate inflammatory common acne, after application, must wash hands. Patients may experience adverse reactions such as itching, burning, irritation, tingling, dry skin, rash, flaking, etc. If allergic or severe irritating reactions occur, patients need to stop using the medication immediately and seek medical attention. 2. Clindamycin gel: Clindamycin gel is a derivative of lincomycin, which has good antibacterial effect on Propionibacterium acnes, and is commonly used in the treatment of acne, however, it sometimes leads to discomforts such as skin dryness and localized irritation, and it may also lead to gastrointestinal discomforts after dermal absorption, which should be paid attention to, avoid contact with eyes and other mucous membranes, and do not use this medicine on broken skin. The above drugs should be used for a long time under the guidance of a doctor, and patients should build up confidence and adhere to the treatment to avoid giving up halfway and leading to deterioration of the condition.