For the replacement of aspirin, the drug that can replace aspirin in the prevention and treatment of coronary heart disease is clopidogrel, which is mainly used after heart attack and plays a dual anti-platelet and anti-platelet role together with aspirin. For patients with gastric ulcers or who cannot tolerate aspirin, consider replacing it with clopidogrel, which replaces aspirin and plays an antiplatelet aggregation role, and can play these key roles for prevention and treatment of heart attack, atherosclerosis, cardiovascular and cerebrovascular diseases, etc. If tolerated, aspirin is preferred as much as possible. In addition to this role, aspirin can also be used for antipyretic and analgesic as well as for the treatment of gout and biliary ascariasis, and the topical powder can treat tinea pedis and Kawasaki disease, etc. Clopidogrel cannot replace aspirin in these areas.