48-year-old impotence refers to erectile dysfunction, which may be caused by psycho-psychological factors, androgen deficiency, hypertension and diabetes and other underlying pathologies, etc. The causes of the disease are different, and the treatments are also different, including general treatment and drug treatment. 1. Psychological factors: usually psychological adjustment, reduce psychological pressure, and more communication with friends, to maintain a stable state of mind, if necessary, should also be combined with oral sildenafil, tadalafil and other drugs for treatment, to help penile erection. 2. Androgen deficiency: excessive lack of androgen in the male body can also lead to impotence, androgen supplementation should be used to regulate the drug, such as testosterone undecanoate pills, and more physical exercise, quit smoking and drinking, reasonable rest. 3. Hypertension and diabetes: For hypertension, the main use of antihypertensive drugs to control, such as nifedipine extended-release tablets. For diabetes mellitus, oral metformin treatment, serious cases also need to inject insulin. If there is discomfort, timely medical treatment, in the process of medication, must follow the doctor’s instructions, reasonable use of medication, do not unauthorized use of drugs to avoid adverse effects.