Rabies hydrophobia is mainly caused by the rabies virus invading the central nervous system. Rabies is caused by rabies virus infection is a zoonotic infectious disease, but also a natural epidemic disease, in our country belongs to category B infectious diseases, so far is still 100% of human morbidity and mortality rate of acute infectious diseases. Fear of water cause specifically for rabies virus erosion of the vagus, lingual pharyngeal, sublingual cerebral nucleus, these positions control the patient’s pharynx, swallowing action, the patient will occur swallowing muscle spasm, respiratory muscle spasm. Once the patient sees or associates water, he or she associates it with the act of swallowing, and for a rabid patient with pharyngeal spasms, swallowing water is tantamount to suicide, as the water may be accidentally inhaled into the trachea leading to asphyxiation. Hydrophobia indicates that the patient is in a period of euphoria, which lasts for a day or two, and then enters a period of paralysis, during which the patient suffers from respiratory paralysis and circulatory paralysis, which can be life-threatening. In general, we should pay attention to the prevention of rabies and control the source of infection. If you have any related symptoms, please seek medical treatment in time to avoid delay.