After eating, if there is significant discomfort in the stomach, first, it is considered to be due to gastric ulcer or gastritis. Secondly, there are also gallbladder diseases that may cause symptoms of discomfort after eating, such as gallstones, chronic cholecystitis or other acute inflammatory diseases, which can lead to significant discomfort after eating. Therefore, a comprehensive blood test should be performed, and treatment can be targeted after understanding the cause. Certain functional gastrointestinal diseases can also lead to significant gastrointestinal discomfort after eating, especially in the elderly population. In addition, stomach tumors can also cause significant symptoms of stomach discomfort. Gastroscopy, colonoscopy, liver and biliary ultrasound and liver function tests should be done, and if necessary, abdominal CT examination should be done to clarify the diagnosis before active treatment.