In clinical practice, we often encounter children who complain of stomach pain, and physical examination and abdominal ultrasound suggest mesenteric lymphadenitis. Most of them occur in the mesenteric lymph nodes at the end of the ileum and are usually associated with respiratory or intestinal infections, mostly viral or bacterial, with streptococcus as the main cause. Once the child is diagnosed with mesenteric lymphadenitis, generally choose conservative treatment, need active antiviral or anti-inflammatory treatment, clearly caused by bacterial infection, to choose the appropriate antibiotics, according to the course of treatment according to the child’s kilogram weight, most of the children in the treatment of 3 to 4 days later, the symptoms can be significantly relieved, generally treatment for a week are able to achieve more satisfactory results, commonly used antibiotics we The common antibiotics we choose are penicillin or cephalosporin, and for children with significant abdominal pain, antispasmodic drugs can also be given for symptomatic treatment. At the same time, during the treatment period, the child should pay attention to his diet, avoiding the intake of cold and stimulating food, too greasy, too sweet food should not be eaten, milk, eggs, fish and shrimp, which can easily cause intestinal allergy food should also be suspended, before and after meals do not strenuous exercise. Pediatric mesenteric lymphadenitis is a relatively common disease, and the prognosis is better with active treatment after a clear diagnosis.