Adrenal medullary adenomas are tumors that occur in the adrenal medulla, sympathetic ganglia, parasympathetic ganglia, or other sites of chromophobic tissue. This tumor releases large amounts of catecholamines either continuously or indirectly, causing episodic hypertension with sympathetic excitation as the main manifestation of clinical symptoms. The secretion of catecholamines by pheochromocytoma is intermittent or persistent, resulting in multi-symptomatic clinical manifestations, including hypertension, headache, palpitations, hypermetabolic state, hyperglycemia, hyperhidrosis, etc. The common signs and symptoms are as follows: 1. Cardiovascular system: Hypertension is the main and characteristic manifestation of this disease, which can be intermittent or persistent episodes. Typical paroxysmal attacks are often characterized by a sudden rise in blood pressure with severe headache, generalized profuse sweating, tachycardia, arrhythmia, a sense of urgency and pain in the precordial region and epigastrium, fear or a sense of near death, pale skin, nausea and vomiting, blurred vision, diplopia, and in severe cases, acute left heart failure or cardiovascular and cerebrovascular accidents. Hypotension, shock:Hypotension or upright hypotension, or even shock or alternating hypertension and hypotension can also occur in this disease. Cardiac lesions:Large amounts of catecholamines can cause catecholamine-induced heart disease, arrhythmias such as pre-term contractions, paroxysmal tachycardia, ventricular fibrillation, long-term, sustained hypertension can cause left ventricular hypertrophy, heart enlargement and heart failure. 2, metabolic disorders high concentrations of adrenaline on the central nervous system, especially the sympathetic nervous system and increased oxygen consumption, increased basal metabolic rate may have fever, wasting symptoms, accelerated decomposition of liver glycogen and inhibition of insulin secretion and reduced glucose tolerance, increased hepatic glucose xenobiotic, a few can appear hypokalemia and hypercalcemia. Some patients may suffer from severe cardiac, cerebral and renal damage due to long-term hypertension or cardiovascular accidents caused by sudden onset of severe hypertension, which may endanger the patient’s life. If diagnosed early, benign adrenal medullary adenoma can be cured by surgery.