Oxaliplatin acts at the same DNA sites as DDP and inhibits DNA synthesis and replication by producing alkylated conjugates that act on DNA to form intra- and interstrand cross-links. It binds to DNA rapidly, taking at most 15 minutes, and produces a DACH group-platinum complex with stronger inhibition of DNA synthesis and cytotoxicity than those produced by cisplatin and carboplatin, with some differences in target molecules and mechanisms of action, and a different spectrum of antitumor activity. 1, lumbar intervertebral disc herniation: lumbar intervertebral disc herniation is a common orthopedic outpatient disorder, mainly because the lumbar intervertebral disc, especially the nucleus pulposus, has different degrees of degenerative changes, under the action of external factors, the intervertebral disc fibrous ring rupture, the nucleus pulposus tissue from the rupture protrudes (or prolapse) in the posterior or spinal canal, stimulating or compressing the adjacent spinal nerve roots to produce lumbar pain and one lower limb or The symptoms of lumbar pain and painful numbness in one or both lower extremities. The incidence of lumbar disc herniation is highest in lumbar 4-5 and lumbar 5-sacral 1, accounting for about 95%. 2, lumbar spine fracture: traumatic type is mostly seen in young adults, and compression fracture is mostly caused by osteoporotic bone in elderly patients. 3, lumbar spine slippage: lumbar spine isthmus refers to the narrow part between the upper and lower articular processes, where the bone structure is relatively weak. The normal lumbar spine has physiological anterior convexity and the sacral spine is physiologically posteriorly convex, and the junction of the lumbar and sacral spine becomes the turning point. The upper lumbar vertebrae are tilted forward, while the lower sacrum is tilted backward, so the negative gravity of the lumbosacral vertebrae naturally forms a forward force, which makes the lumbar 5 have a tendency to slide forward. Under normal circumstances, the force of the lower lumbar 5 articular eminence and the surrounding joint capsule and ligaments can limit this tendency to slip, thus leaving the lumbar 5 isthmus at the intersection of the two forces, and therefore the isthmus is prone to disintegration, which is the reason why the lumbar 5 isthmus disintegrates the most. After isthmus disintegration, the vertebral arch is divided into two parts: the upper part is the superior articular process, transverse process, vertebral roots, and vertebral body, which still maintain normal connection with the spine above; the lower part is the inferior articular process, vertebral plate, and spinous process, which maintain connection with the sacral spine below. The loss of bony connection between the two parts and the forward displacement of the upper part due to loss of restriction is manifested by the forward slippage of the vertebral body on the vertebral body below, which is called lumbar spine slippage. 4, lumbar spine osteophytes 5, scoliosis 6, lumbar spine tumors 7, kidney stones 8, ankylosing spondylitis 9, lumbar spine tuberculosis 10, lumbar spinal stenosis 11, lumbar back muscle injury