Sciatic nerve related diseases can be treated by applying non-steroidal anti-inflammatory drugs (NSAIDs), neuroedema eliminators, and neurotrophic drugs. 1. Non-steroidal anti-inflammatory drugs: Oral administration of non-steroidal anti-inflammatory and analgesic drugs, such as ibuprofen, celecoxib, and rosoprofen sodium, under doctor’s supervision, which can reduce the inflammatory reaction of the sciatic nerve and alleviate the pain caused by the compression of or damage to the sciatic nerve. 2. Elimination of neuroedema drugs: can follow the doctor’s instructions to apply the MaiZhiLing, mannitol, glycerol fructose, glucocorticoids and other elimination of neuroedema drugs, can reduce sciatic nerve edema, restore the normal blood supply to the nerves, and help to improve the numbness and pain produced by the nerve compression symptoms. 3. Nutritional nerve drugs: vitamin B1, methylcobalamin and other nutritional nerve drugs can be used under the guidance of the doctor, which can promote the repair of sciatic nerve damage and help to restore the normal conduction function of the nerve. Sciatic nerve related diseases need to consult a doctor to clarify the condition, and medications can be applied under the guidance of the doctor, which will help the early recovery of the disease.