Toothache will usually be relieved to varying degrees 0.5-2 hours after taking ibuprofen. However, the exact time of onset of action varies depending on the individual’s physical condition and degree of symptoms. Ibuprofen belongs to the class of NSAIDs and is commonly used in clinical practice to treat pain, fever or other discomfort caused by various diseases. Pain symptoms include joint pain, migraine, toothache, etc. In addition, it is also a non-selective cyclooxygenase inhibitor, which can reduce the efficiency of synthesis of prostaglandins, thromboxane precursors and other substances in the body by inhibiting the activity of cyclooxygenase I and II, thus serving to alleviate various types of adverse symptom reactions. Patients usually see an effect about half an hour after taking the drug orally, and the peak concentration of the drug in the body is reached after 1-2 hours. Most ibuprofen is metabolized in the urine within 24 hours. It should be noted that patients should avoid taking ibuprofen with anticoagulant and hypotensive types of drugs such as furosemide, nifedipine, digoxin, etc. while taking ibuprofen to avoid increasing the risk of adverse symptomatic reactions.