Lung adenocarcinoma 10cm can be treated by surgery, chemotherapy, targeted therapy and radiotherapy under the guidance of doctors. 1. Surgery: patients with lung adenocarcinoma 10cm can undergo lobectomy and hilar mediastinal lymph node dissection, but surgery is not recommended if patients have already developed intrathoracic metastasis or distant metastasis. 2. Chemotherapy: for people who cannot undergo surgery or after surgery for stage II or III lung adenocarcinoma, chemotherapy can also be carried out, and commonly used chemotherapeutic drugs include cisplatin, carboplatin, gemcitabine and so on. 3. Targeted therapy: patients with lung adenocarcinoma of 10 cm can also undergo targeted therapy, commonly used targeted drugs include gefitinib, afatinib, etc. These drugs can inhibit the growth of tumor and achieve the purpose of treating lung adenocarcinoma. 4. Radiation therapy: patients with lung adenocarcinoma of 10 centimeters can also undergo radiation therapy, and patients with more limited lesions or inoperable patients can undergo radical radiotherapy. Patients with lung adenocarcinoma can also undergo palliative radiotherapy, which can delay the spread of tumor and improve the symptoms of persistent cough and hemoptysis. Patients with lung adenocarcinoma of 10 cm are recommended to be admitted to hospital for examination and standardized treatment according to their conditions under the guidance of doctors.