Many people with Parkinson’s disease do not know that this is a Parkinson’s disease symptom when they have hand tremors, or feel stiffness and inflexibility in their limbs, and they do not know which department to see. Some hang up orthopedics, some let Chinese medicine doctors see them, and some see them in the local community and do a series of tests such as blood draws, EMG, ECG, brain CT, etc. They find problems to treat and no problems to not treat, but they do not really solve the symptoms. It was only after a few turnarounds that they found a neurologist and learned that they were suffering from Parkinson’s disease because of a problem with the nerves in the brain, not a cervical spine thing, and thus began to treat it properly. So what is wrong with the brain in Parkinson’s disease? We know that the brain is the supreme commander of the human body, human movement, sensation, emotion, etc. are controlled by the brain, and are cross-controlled, that is, the left half of the brain dominates the right half of the body. Every tiny action is participated by many parts of the brain, including collecting information, recognizing and processing, giving feedback instructions and completing the action. This information is collected and gathered in an area of the brain called the striatum, which then works with other parts of the brain (including the substantia nigra of the midbrain) to send out instructions for balancing and coordinating body movements so that the body can move freely or remain still. Parkinson’s disease is caused by lesions in the substantia nigra and striatum of the midbrain, where the neurotransmitter dopamine is made and stored, while dopamine is the inhibitory neurotransmitter of the striatum and acetylcholine is the excitatory neurotransmitter of the striatum. When a large number of nigrostriatal cells in the brain are lost, the production of dopamine decreases, and the level of dopamine in the brain decreases, while the level of acetylcholine remains at the original “normal” level, the original balance between the dopamine system and the acetylcholine system is disrupted. The balance between dopamine and other neurotransmitters can be disrupted by too much or too little dopamine release, affecting the continuity and flow of movement. Once dopamine levels in the brain fall below 20% of normal, acetylcholine is relatively hyperactive and Parkinson’s disease symptoms such as limb tremors, stiffness, and slowness follow. However, current brain CT and brain MRI can detect brain tumors, brain infarction, brain atrophy and other lesions, but not lesions in the substantia nigra. These tests can be used as a basis for differentiating primary Parkinson’s disease from secondary Parkinson’s disease and Parkinson’s superposition syndrome. Finally, we hope that people can recognize Parkinson’s disease and identify its symptoms, such as limb tremors, shaking at rest, muscle stiffness, inflexible activities, slow movements, ape posture, mask face, writing is getting smaller and smaller, walking with dragging steps, arms not throwing, unable to brake, small broken steps, difficulty in starting, etc. If these symptoms are found, promptly register for neurology or functional neurosurgery consultation.