Neonatal acne is a physiological phenomenon that can be treated without treatment and can recover after the child is full term. If the condition worsens, mupirocin ointment or fusidic acid ointment can be applied to the affected area once a day. Neonatal acne is not a disease, and healthy children can also get it. The mechanism is not completely clear, and it may be related to the excessive hormones given by the mother during birth. In a small number of children with slow metabolism, it takes 6-8 weeks to complete. For some children with severe symptoms, topical Bactrim can be used once a day for good results. There are also a very small number of children with combined fungal infections, combined with ketoconazole cream or boutinafine ointment can receive good results. In addition to medication, life should be cool and not stuffy, and pediatric moisturizers should be used appropriately (recommended medical brands, such as Winona, Richland, Avène, etc. Medical moisturizers such as vitamin E ointment are also available). Newborn acne should be distinguished from eczema. The former occurs in children within one month, with a white tip to the rash, while eczema occurs in babies after the first month, and can have a dry and peeling surface. Particular attention should be paid to the fact that in some children, eczema occurs after acne has healed.