Glomerular filtration rate may fluctuate each time the test is performed, mainly because the glomerular filtration rate is not directly detected in the clinic, but is estimated based on the blood creatinine and other values, which can change with the changes of renal function as well as the changes of blood creatinine and other test values. Glomerular filtration rate can more accurately reflect the glomerular filtration function and the metabolic capacity of the kidney. The glomerular filtration rate is usually affected by age, weight, diet, exercise, disease and other factors, and its normal value is usually 80-120ml/min. The normal value is 80~120ml/min. It usually fluctuates with the change of renal function, and if it fluctuates within the normal range, it is a normal phenomenon. Generally speaking, as the age increases, the glomerular filtration rate will gradually decline; the glomerular filtration rate of pregnant women will appear to be elevated, but after giving birth, it will gradually return to within the normal range. If the glomerular filtration rate of the patient is increased, we should also consider whether the patient is suffering from primary kidney disease or secondary kidney disease, such as primary nephrotic syndrome, diabetic glomerulosclerosis, microscopic lesion nephrotic syndrome. If patients find glomerular filtration rate abnormalities or experience discomfort, it is recommended to consult a doctor in a timely manner and follow the doctor’s instructions for standardized diagnosis and treatment, so as to avoid delaying the condition.